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Comment & Response
September 19, 2019

Immune Thrombocytopenia—A Neglected Adverse Event of PD-1 and PD-L1 Inhibitors in Clinical Trials—In Reply

Author Affiliations
  • 1Division of Hematology, Mayo Clinic, Rochester, Minnesota
  • 2The Comprehensive Cancer Centre of Drum Tower Hospital, Clinical Cancer Institute of Nanjing University, Nanjing, China
  • 3Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston
JAMA Oncol. 2019;5(11):1641-1642. doi:10.1001/jamaoncol.2019.3608

In Reply Pang et al raised the concern of immune thrombocytopenia being neglected as an adverse event associated with programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors in clinical trials. This perceived oversight may have stemmed from the low incidence of thrombocytopenia reported in clinical trials of PD-1 and PD-L1 inhibitors, the challenge in diagnosing immune thrombocytopenia, and the potential life-threatening severity of immune thrombocytopenia in rare cases.

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