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Comment & Response
October 10, 2019

Potential Areas of Interest in a Trial of Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin for Hepatocellular Carcinoma

Author Affiliations
  • 1Department of Gastroenterology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
JAMA Oncol. 2019;5(12):1805-1806. doi:10.1001/jamaoncol.2019.4052

To the Editor We read with interest the article published by He et al1 focusing on sorafenib with hepatic arterial infusion of chemotherapy (HAIC). He et al1 conducted an open-label phase 3 randomized clinical trial with HAIC using leucovorin calcium, fluorouracil, and oxaliplatin (FOLFOX) in addition to sorafenib vs sorafenib alone in patients with hepatocellular carcinoma (HCC) and a portal vein tumor thrombosis. The study met its primary end point, median overall survival, and identified an interesting overall response rate (ORR) in this situation (40.8%).

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