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Comment & Response
October 17, 2019

Correcting the Conclusion in a Study of Frameworks for Measurement of Absolute or Relative Clinical Survival Benefit

Author Affiliations
  • 1National and Kapodistrian University of Athens, Athens, Greece
  • 2Shaare Zedek Medical Center, Jerusalem, Israel
  • 3University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
JAMA Oncol. Published online October 17, 2019. doi:https://doi.org/10.1001/jamaoncol.2019.4091

To the Editor Saluja et al1 evaluated the correlation of the European Society for Medical Oncology’s Magnitude of Clinical Benefit Scale (ESMO-MCBS) and the American Society of Clinical Oncology’s Value Framework (ASCO-VF) with absolute and relative survival measures, including the algorithmically calculated restricted mean survival time (RMST) derived from published Kaplan-Meier curves. Their conclusion regarding the shared inadequacy of ASCO-VF and ESMO-MCBS is based heavily on an unsubstantiated premise regarding RMST as a gold standard for evaluating survival benefit, and it is inconsistent with the results.

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