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Comment & Response
November 21, 2019

Going Beyond Results of the PEMBRO-RT Trial—Reply

Author Affiliations
  • 1Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands
JAMA Oncol. Published online November 21, 2019. doi:https://doi.org/10.1001/jamaoncol.2019.5034

In Reply We would like to thank Zhang and Han and Yang and colleagues for their appreciation of our work in the PEMBRO-RT trial.1 Both letters address the need for additional research on different radiotherapy modalities in combination with immunotherapy. We agree that our phase 2 study leaves many questions unanswered about the possibilities of this treatment combination. However, in 2019, use of pembrolizumab with or without the addition of chemotherapy became the standard of care in the first-line treatment of advanced non–small cell lung cancer, as pointed out by Yang and colleagues. Our pembrolizumab monotherapy setting enabled us to generate hypotheses without a possible interference of chemotherapy effects, especially in the subgroups with lower PD-L1 expression. Indeed, these hypotheses will need to be tested and translated to the new treatment landscape.

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