Populationwide breast cancer screening programs have been established in many countries to reduce breast cancer mortality through early detection and treatment. These programs offer routine mammographic screening to women at average risk starting at age 40 to 50 years with frequency of 1 to 3 years and enhanced screening starting at earlier ages to women at elevated risk owing to family history or genetic susceptibility from high-penetrance genetic mutations (eg, in BRCA1/2 or TP53).1 Screening guidelines recommend different approaches to identify women at elevated risk, including the use of risk prediction models with pedigree-level family history information and genetic testing.
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Gierach GL, Choudhury PP, García-Closas M. Toward Risk-Stratified Breast Cancer Screening: Considerations for Changes in Screening Guidelines. JAMA Oncol. 2020;6(1):31–33. doi:10.1001/jamaoncol.2019.3820
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