To the Editor We read with much interest the Original Investigation by Banerjee et al.1 The authors found that accumulated anesthesia exposures may be associated with poor neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia (ALL). The authors suggested that anesthesia exposures should be limited in pediatric patients with chronic health conditions who undergo multiple medical procedures. Given that millions of children worldwide receive anesthesia and sedation for various purposes, the study results and implications may raise important public health concerns. We wish to highlight some important limitations in the methods used to estimate associations between anesthesia exposures and neurocognitive outcomes.
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Ishida S, Kuratani N. Association of Anesthesia Care and Cognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia. JAMA Oncol. Published online November 14, 2019. doi:https://doi.org/10.1001/jamaoncol.2019.4897
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