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Comment & Response
November 27, 2019

Different Biomarker Modalities and Response to Anti–PD-1/PD-L1 Therapies

Author Affiliations
  • 1Graduate School, Beijing University of Chinese Medicine, Beijing, China
  • 2Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
  • 3Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China
JAMA Oncol. Published online November 27, 2019. doi:https://doi.org/10.1001/jamaoncol.2019.5148

To the Editor In a systematic review and meta-analysis, Lu and colleagues1 provided an overview of the most common tissue-based biomarker approaches for predicting response to anti–PD-1/PD-L1 (programmed cell death 1/programmed cell death 1 ligand 1) therapies and reported a higher diagnostic accuracy of multiplex immunohistochemistry/immunofluorescence compared with PD-L1 immunohistochemistry, tumor mutational burden, or gene expression profiling alone. However, we have 2 points of concern related to the methodological aspects of this systematic review and meta-analysis.

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