[Skip to Navigation]
Sign In
Views 512
Citations 0
Comment & Response
November 27, 2019

Application of the Lung Immune Prognostic Index From Research to Clinical Practice—Reply

Author Affiliations
  • 1Oncology Center of Excellence and Office of Hematology and Oncology Products, US Food and Drug Administration, Silver Spring, Maryland
  • 2Multiple Myeloma Program, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
JAMA Oncol. 2020;6(2):300-301. doi:10.1001/jamaoncol.2019.5157

In Reply We thank Long et al for critically evaluating our study1 on the prognostic value of the lung immune prognostic index (LIPI) for patients treated for non–small cell lung cancer and for proposing 3 future clinical practice points, which we will address below. First, Long et al propose that different treatments require varying cutoff values for the neutrophil to lymphocyte ratio. Although we agree that it is important to use the appropriate cutoff and that results might vary depending on that value, our study evaluated baseline values prior to treatment. We showed that a prespecified neutrophil to lymphocyte ratio and lactate dehydrogenase level composite score can identify patients who are likely to have longer survival independent of treatment type (eg, immunotherapy, targeted therapy, chemotherapy). Our analysis did not aim to define a new cutoff value; rather, its intent was to validate the findings by Mezquita et al.2 Furthermore, Sorich et al,3 while our article was in press, published their findings, which similarly show that LIPI (using the original cutoff values) is prognostic for patients irrespective of whether they received immune checkpoint inhibitors or cytotoxic chemotherapy.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words