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December 5, 2019

Survival in Oligometastatic Prostate Cancer—A New Dawn or the Will Rogers Phenomenon?

Author Affiliations
  • 1Imperial Prostate, Department of Surgery and Cancer, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London, United Kingdom
  • 2Imperial College Healthcare Nationals Health Service Trust, Department of Urology, Charing Cross Hospital, London, United Kingdom
JAMA Oncol. 2020;6(2):185-186. doi:10.1001/jamaoncol.2019.4724

Oligometastatic prostate cancer refers to the cases affecting a group of patients with a potentially highly favorable limited metastatic state, defined exclusively by clinical features.1 The cases affecting this group challenge the long-held oncological paradigm that metastasis from solid-organ malignant conditions are not controllable and thus should be managed with palliative intent. In the wake of the US Preventive Services Task Force 2012 recommendation against routine prostate-specific antigen screening, de novo metastatic prostate cancer incidence has experienced a relative increase of 57.1% (from 4.9% to 7.7%; P = .08), equating to an expected 15 097 diagnoses per year by 2025.2 Nonetheless, overall survival in this group of patients has also dramatically increased with the use of early, novel systemic agents, such as docetaxel.3

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