In this issue of JAMA Oncology, Baumann et al1 present a large single-institution retrospective analysis of proton- vs photon-based radiotherapy specifically for patients receiving concurrent chemotherapy for 11 types of locally advanced cancers. Patients undergoing proton therapy overall had significantly fewer grade 3 toxic effects requiring hospitalization at 90 days, as well as fewer grade 2 toxic effects at 90 days and a smaller decline in performance status during treatment.
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Park HS, Yu JB. Proton-Based Chemoradiotherapy—What Level of Evidence Is Necessary to Justify Its Widespread Use? JAMA Oncol. 2020;6(2):246–247. doi:10.1001/jamaoncol.2019.4875
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