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Comment & Response
January 30, 2020

Variant Interpretation in Patients With Metastatic Breast Cancer—Reply

Author Affiliations
  • 1Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
JAMA Oncol. 2020;6(4):582-583. doi:10.1001/jamaoncol.2019.6409

In Reply We thank Fostira and Konstantopoulou for their comments regarding our study.1 Indeed, the initial focus of our work was to determine whether patients with metastatic breast cancer might benefit from the recent US Food and Drug Administration approval of polyadenosine diphosphate–ribose polymerase inhibitors if tested in a relatively unbiased way. We acknowledge that patients with pathogenic BRCA1/2 variants all met National Comprehensive Cancer Network guidelines, as mentioned in our article.1 However, equally important, 2 of 6 patients were never tested despite meeting guidelines, which underscores the need for increased dissemination and implementation of germline testing for optimal patient care.

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