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Comment & Response
February 6, 2020

Using Real-World Historical Controls to Evaluate Radiation Dose Escalation in Esophageal Cancer—Reply

Author Affiliations
  • 1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston
  • 2Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston
JAMA Oncol. Published online February 6, 2020. doi:10.1001/jamaoncol.2019.6412

In Reply We thank Fan and colleagues for their interest in our recent phase 1/2 trial evaluating the use of chemoradiotherapy with a simultaneous integrated boost of radiation in unresectable locally advanced esophageal cancer.1 First, we are delighted to present more details regarding the cohort of 97 patients used for comparison in our investigation. This patient cohort is the same group we used as the historical control in our previous interim analysis,2 in which we described the selection criteria. Briefly, all 97 of the historical cohort patients with unresectable esophageal cancer were treated at the University of Texas MD Anderson Cancer Center with chemoradiation (50.4 Gy in 28 fractions) using intensity-modulated radiotherapy and a simultaneous integrated boost. The patients were reviewed from an accessible partial data set of 239 total patients previously created from a separate analysis.3

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