To the Editor Sun et al1 conducted a cost-effectiveness analysis of multigene testing among women with breast cancer. The authors state that multiple genetic tests have the potential to reveal more variation (formerly mutation) carriers when an unselected population of patients with breast cancer are targeted and could be more cost-effective in UK and US health systems compared with current family history–based population screenings. This research highlights the importance of screening of an unselected population with breast cancer, which could have an immediate translational influence on patient outcomes. We offer a few suggestions that could help to further strengthen the approach.
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Jun I, Berger AL, Yaghjyan L. Future Research Suggestions for Multigene Testing in Unselected Populations. JAMA Oncol. Published online March 26, 2020. doi:10.1001/jamaoncol.2020.0128
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