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Comment & Response
March 26, 2020

Future Research Suggestions for Multigene Testing in Unselected Populations

Author Affiliations
  • 1Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville
JAMA Oncol. 2020;6(5):785. doi:10.1001/jamaoncol.2020.0128

To the Editor Sun et al1 conducted a cost-effectiveness analysis of multigene testing among women with breast cancer. The authors state that multiple genetic tests have the potential to reveal more variation (formerly mutation) carriers when an unselected population of patients with breast cancer are targeted and could be more cost-effective in UK and US health systems compared with current family history–based population screenings. This research highlights the importance of screening of an unselected population with breast cancer, which could have an immediate translational influence on patient outcomes. We offer a few suggestions that could help to further strengthen the approach.

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