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Comment & Response
April 9, 2020

Locoregional Therapy Plus Systemic Chemotherapy in Unresectable Intrahepatic Cholangiocarcinoma

Author Affiliations
  • 1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 2Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
JAMA Oncol. Published online April 9, 2020. doi:10.1001/jamaoncol.2020.0340

To the Editor The study by Cercek et al1 in JAMA Oncology was inspiring. It detailed a phase 2 single-arm study to evaluate and validate the efficacy and safety of combining hepatic arterial infusion (HAI) of floxuridine (14-day infusion, 4-week cycle) with systemic gemcitabine and oxaliplatin in patients (N = 38) with unresectable intrahepatic cholangiocarcinoma (IHC). The median progression-free survival (PFS) was 11.8 months (1-sided 90% CI, 11.1), and the overall survival (OS) was 25.0 months (95% CI, 20.6-not reached).1 Herein, we present several concerns about the study outcomes.

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