Clinical trial data demonstrate poly–(adenosine diphosphate–ribose) polymerase (PARP) inhibitor drug efficacy in individuals with BRCA1/2 pathogenic variants, but not all germline pathogenic variant carriers respond, and some without germline pathogenic variants also derive significant benefit. [18F]FluorThanatrace ([18F]FTT) is a radiolabeled PARP inhibitor that enables noninvasive quantification of PARP-1.1,2 In vitro data demonstrate that the level of PARP-1 correlates positively with cytotoxicity of PARP inhibitors2 and that PARP-1 expression is required for PARP inhibitor efficacy.1-4 In this prospective nonrandomized clinical trial, we report on PARP-1 positron emission tomography imaging using [18F]FTT in patients with breast cancer across a range of breast cancer phenotypes. These proof-of-concept results provide support for testing [18F]FTT as a method for measuring regional PARP-1 expression in breast cancer and as a potential functional biomarker for breast cancer PARP inhibitor response.
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McDonald ES, Doot RK, Pantel AR, et al. Positron Emission Tomography Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol. 2020;6(6):921–923. doi:10.1001/jamaoncol.2020.0334
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