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Comment & Response
April 16, 2020

The Role of Maintenance Therapy in Metastatic Colorectal Cancer—Reply

Author Affiliations
  • 1Division of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona
  • 2Evidence-Based Practice Research Program, Mayo Clinic, Rochester, Minnesota
JAMA Oncol. Published online April 16, 2020. doi:10.1001/jamaoncol.2020.0583

In Reply We thank Wang et al for their interest in our recent article.1 The information requested by Wang et al is in fact in the published manuscript. Regarding which trials of the 11 were included in the network meta-analysis, we refer Wang et al to the original manuscript, in which we cited all included trials for each comparison. In addition, as mentioned in the Study Selection paragraph in the Results section,1 all 12 trials were included in the quantitative analysis except for the Combined Oxaliplatin Neurotoxicity Prevention Trial (CONCEPT). Figure 2 of our article1 clearly shows the direct comparison with efficacy data as reported by the included studies. For the studies where the data were not available (as in the AIO 0207, Stop and Go, and OPTIMOX2 trials), imputed hazard ratios were included in the network meta-analysis.1

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