[Skip to Content]
[Skip to Content Landing]
Views 98
Citations 0
Comment & Response
May 7, 2020

Determining the Appropriate Risk-Adapted Screening Age for Familial Breast Cancer—Reply

Author Affiliations
  • 1Risk Adapted Prevention Group, Division of Preventive Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany
JAMA Oncol. Published online May 7, 2020. doi:10.1001/jamaoncol.2020.0292

In Reply We thank Hemminki for his comments on our proposed risk-adapted starting age of screening in women (not patients, as written in the first sentence of the comments) with a family history of breast cancer.1 Hemminki compared our results with those in an article written in 2010 by Brandt and colleagues,2 including Hemminki and a coauthor of our article, although results of these studies with different risk measures should not be compared in the first place. Prediction of age-specific 10-year cumulative risk (ie, risk of developing breast cancer in the next 10 years at each age) presented in our study1 and comparison with a threshold risk in women at the age of initial screening in the general population has clinical relevance and application, whereas it is hard to find a clear application for comparing cumulative risk (ie, risk from birth to a certain age) between those with a family history and those without a family history, which was presented in their study.2

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×