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Comment & Response
May 28, 2020

Analysis of Overall Survival Benefit of Abemaciclib Plus Fulvestrant in Hormone Receptor–Positive, ERBB2-Negative Breast Cancer

Author Affiliations
  • 1Pharmacology Department, University of Sevilla, Sevilla, Spain
  • 2Pharmacy Department, Hospital Universitario de Puerto Real, Puerto Real, Spain
JAMA Oncol. 2020;6(7):1122. doi:10.1001/jamaoncol.2020.1516

To the Editor The MONARCH 2 trial1 compared fulvestrant in combination with abemaciclib or placebo in patients with hormone receptor–positive, ERBB2-negative advanced breast cancer after progression to a prior endocrine therapy. Sledge and colleagues concluded that greater benefits were found in subgroups of patients with visceral metastasis and primary endocrine therapy resistance. This statement is based on earlier separation of the graphical curves and a numerically larger effect observed in overall survival (OS). However, no statistical interaction was presented in these subsets.

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