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Comment & Response
September 3, 2020

Demystifying the Role of Tumor Mutational Burden for Immunotherapy Selection

Author Affiliations
  • 1Foundation Medicine Inc, Cambridge, Massachusetts
JAMA Oncol. Published online September 3, 2020. doi:10.1001/jamaoncol.2020.3386

To the Editor In their Invited Commentary, Waqar and Govindan1 describe some of the confounding factors that may have influenced the outcomes of 2 pivotal studies—the Checkmate 227 study (NCT02453282) and the MYSTIC study (NCT02477826)—that evaluated the ability of tumor mutational burden (TMB) to enrich survival in patients treated with immunotherapy vs standard of care. While important, their commentary falls short of fully characterizing the current landscape of TMB as an immunotherapy-guided biomarker.

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