To the Editor In their Invited Commentary, Waqar and Govindan1 describe some of the confounding factors that may have influenced the outcomes of 2 pivotal studies—the Checkmate 227 study (NCT02453282) and the MYSTIC study (NCT02477826)—that evaluated the ability of tumor mutational burden (TMB) to enrich survival in patients treated with immunotherapy vs standard of care. While important, their commentary falls short of fully characterizing the current landscape of TMB as an immunotherapy-guided biomarker.
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Fabrizio DA, Hegde P, Alexander B. Demystifying the Role of Tumor Mutational Burden for Immunotherapy Selection. JAMA Oncol. Published online September 03, 2020. doi:10.1001/jamaoncol.2020.3386
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