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Comment & Response
September 10, 2020

Safety of Anti–PD-L1 Inhibition in HIV-1–Infected Patients With Cancer

Author Affiliations
  • 1Department of Internal Medicine, Haaglanden Medisch Centrum, The Hague, The Netherlands
JAMA Oncol. Published online September 10, 2020. doi:10.1001/jamaoncol.2020.3389

To the Editor In their Brief Report in JAMA Oncology, Gonzalez-Cao et al1 sought to evaluate the safety of durvalumab in HIV-1–infected patients with advanced cancer. The authors cite immune reconstitution inflammatory syndrome (IRIS) as a safety concern for this patient population. Although theoretically conceivable, the occurrence of IRIS when starting checkpoint inhibition in HIV-1–infected patients has thus far been entirely a hypothetical concern. With the DURVAST study results, the authors conclude that treatment with durvalumab is safe.1 Whether their claim extends to all HIV-1–infected patients with cancer is unknown.

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