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Comment & Response
September 24, 2020

Recurrence of Immune-Related Adverse Events After Immune Checkpoint Inhibitor Rechallenge

Author Affiliations
  • 1Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China
JAMA Oncol. 2020;6(11):1813-1814. doi:10.1001/jamaoncol.2020.3955

To the Editor Immune checkpoint inhibitor (ICI) rechallenge is increasingly attracting attention. Making full use of immunotherapies is necessary to maximize the curative effect given our current understanding. In a recently published article, Dolladille and colleagues1 reported the recurrence rate of initial immune-related adverse events (irAEs) after an ICI rechallenge. Their study included all types of cancer and multiple ICI regimens based on the VigiBase database and found a 28.8% recurrence rate of the same irAE after rechallenge with the same ICI.1 While this was undoubtedly rigorously conducted and informative, there are several concerns that must be addressed.

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