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Comment & Response
October 22, 2020

Need for More Comprehensive Evaluation of Immune-Related Adverse Events in Immunotherapy for Biliary Tract Cancer

Author Affiliations
  • 1Peking Union Medical College Hospital, Department of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 2Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College School of Humanities and Social Sciences, Beijing, China
JAMA Oncol. 2020;6(12):1981. doi:10.1001/jamaoncol.2020.4815

To the Editor Uncertainty remains around the efficacy of programmed cell death 1 (PD-1) inhibitors for treatment of advanced biliary tract cancer (objective response rate [ORR], 3%-22%).1 Recently, Kim et al2 reported a multicenter phase 2 study of nivolumab in a single group of patients with refractory biliary tract cancer and found an ORR of 22% with a median progression-free survival of 4.0 months. To our knowledge, this is the highest ORR for PD-1/programmed cell death ligand 1 blockade monotherapies achieved in biliary tract cancer, but there are several concerns that should be discussed.

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