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Invited Commentary
February 18, 2021

More Answers and More Questions About Radiotherapy for Metastatic Prostate Cancer

Author Affiliations
  • 1Department of Radiation Oncology, Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina
  • 2Department of Radiology and Biomedical Imaging, University of California, San Francisco
JAMA Oncol. 2021;7(4):563-564. doi:10.1001/jamaoncol.2020.7708

The phase 3 multiarm, multistage STAMPEDE trial has been a tour de force in prostate cancer—its design has allowed efficient evaluation of pressing questions in the management of high-risk and metastatic prostate cancer resulting in practice change multiple times over. The publication by Parker et al1 in Lancet in 2018 was one of STAMPEDE’s landmark comparisons. While the hypothesis that prostate radiotherapy (RT) would improve overall survival (OS) was negative for the population as a whole, the study enrolled sufficient patients that a planned analysis of metastatic burden showed that RT did improve OS in men with a low metastatic burden.

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