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Research Letter
March 18, 2021

Association Between Antiangiogenic Drugs Used for Cancer Treatment and Artery Dissections or Aneurysms

Author Affiliations
  • 1Angiogenesis and Cancer Microenvironment Laboratory, Univ. Bordeaux, Inserm U1029, Pessac, France
  • 2Department of Clinical Pharmacology, Bordeaux University Hospital, Univ. Bordeaux, Inserm U1219, Bordeaux, France
  • 3Univ. Bordeaux, Inserm U1219, Bordeaux, France
  • 4Unit of Vascular Surgery, Bordeaux University Hospital, Univ. Bordeaux, Bordeaux, France
JAMA Oncol. Published online March 18, 2021. doi:10.1001/jamaoncol.2021.0210

Anticancer drugs targeting angiogenesis act either directly on vascular endothelial growth factor (VEGF) receptors (VEGF inhibitors) or VEGF-mediated intracellular processes (tyrosine kinase inhibitors) or indirectly through downstream VEGF signaling within broader processes (mammalian target of rapamycin inhibitors and multiprotein kinase inhibitors). Although VEGF blockade may be implicated in arterial wall injuries, the literature on the association between antiangiogenic drugs and artery dissections or aneurysms is scant, comprising only a few case reports and 1 pharmacovigilance study conducted in Japan.1 The present study evaluated the association between all antiangiogenic drugs and dissections or aneurysms occurring in all arteries.

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