To the Editor In their cohort study, Mackintosh and colleagues1 found a statistically significant association between coffee consumption and improved overall survival (OS) in patients with metastatic colorectal cancer (CRC). In the Conclusions, they note that “this is the first such study…to show a protective effect of coffee consumption in patients with advanced or metastatic CRC.” This conclusion, however, seems to be unduly influenced by the rather small fraction of patients (63 patients, or 5.4% of a total enrolled 1171 patients) who reported drinking at least 4 cups of coffee daily.
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Tan IT, Lin AY. Coffee Consumption and Colorectal Cancer Prognosis. JAMA Oncol. 2021;7(5):778–779. doi:10.1001/jamaoncol.2020.8485
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