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Comment & Response
April 8, 2021

Comparison of Therapy in Advanced Hepatocellular Carcinoma Based on Clear Definition and Accurate Subgroup Data

Author Affiliations
  • 1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
JAMA Oncol. 2021;7(6):940-941. doi:10.1001/jamaoncol.2021.0531

To the Editor The treatment landscape of advanced hepatocellular carcinoma (HCC) has significantly changed in recent years. We applaud that Sonbol and colleagues1 conducted a systematic review and network meta-analysis providing a more systematic understanding of advanced HCC treatment options, irrespective of first-line or second-line setting. Herein, we raise several concerns.

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