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Comment & Response
June 17, 2021

Is Universal Next-Generation Sequencing Testing of Patients With Advanced Cancer Ready for Prime Time?

Author Affiliations
  • 1Personalised Medicine Division, Walter and Eliza Hall Research Institute, Melbourne, Victoria, Australia
  • 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
JAMA Oncol. 2021;7(8):1246. doi:10.1001/jamaoncol.2021.1904

To the Editor Precision oncology offers thrilling therapeutic possibilities, as demonstrated by Cobain and colleagues1 in their cohort study. We do, however, have concerns regarding the generalizability of their findings, in particular, the expansive recommendation for “directed germline testing in all patients with advanced cancer.”1(p525)

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