[Skip to Navigation]
Sign In
Views 530
Citations 0
Comment & Response
July 1, 2021

Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or BRCA2 Pathogenic Variants—Caution Needed—Reply

Author Affiliations
  • 1Department of Epidemiology and Biostatistics, Western University, London, Canada
  • 2Mailman School of Public Health, Columbia University, New York and the Herbert Irving Comprehensive Cancer Center, Columbia Irving Medical Center, New York, New York
  • 3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada
  • 4Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
JAMA Oncol. 2021;7(9):1402. doi:10.1001/jamaoncol.2021.2040

In Reply We thank Conduit and colleagues for their comments on our Original Investigation1 and firmly agree that it is essential to carefully consider the full range of biases that may be present when reviewing the evidence regarding risk-reducing salpingo-oophorectomy (RRSO) and breast cancer (BC) risk.2 We find that the statistical inference for RRSO and BC risk is sensitive to underlying assumptions of the association over time.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words