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Comment & Response
July 1, 2021

Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or BRCA2 Pathogenic Variants—Caution Needed—Reply

Author Affiliations
  • 1Department of Epidemiology and Biostatistics, Western University, London, Canada
  • 2Mailman School of Public Health, Columbia University, New York and the Herbert Irving Comprehensive Cancer Center, Columbia Irving Medical Center, New York, New York
  • 3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada
  • 4Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
JAMA Oncol. 2021;7(9):1402. doi:10.1001/jamaoncol.2021.2040

In Reply We thank Conduit and colleagues for their comments on our Original Investigation1 and firmly agree that it is essential to carefully consider the full range of biases that may be present when reviewing the evidence regarding risk-reducing salpingo-oophorectomy (RRSO) and breast cancer (BC) risk.2 We find that the statistical inference for RRSO and BC risk is sensitive to underlying assumptions of the association over time.

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