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Comment & Response
July 1, 2021

Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or BRCA2 Pathogenic Variants—Caution Needed

Author Affiliations
  • 1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
  • 2Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia
  • 3Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia
  • 4Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia
  • 5Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia
JAMA Oncol. 2021;7(9):1401. doi:10.1001/jamaoncol.2021.2037

To the Editor The study by Choi et al1 evaluated risk-reducing salpingo-oophorectomy (RRSO) as a breast cancer prevention strategy in women with pathogenic germline BRCA1 and BRCA2 variants. This issue is of critical importance to women with these variants and to the clinicians who care for them. Unlike some other contemporary studies of this issue,2-5 Choi et al1 reported an association of RRSO with a reduction in breast cancer risk in women carrying BRCA1 and BRCA2 pathogenic gene variants. However, the study appears to have several methodological limitations, which means the results should be interpreted with caution.

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