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Invited Commentary
July 1, 2021

Unravelling the Mechanisms of Cancer-Related Cognitive Dysfunction in Non–Central Nervous System Cancer

Author Affiliations
  • 1Department of Neurosurgery, University of California, San Francisco
  • 2Department of Neurology, Stanford University, Stanford, California
JAMA Oncol. Published online July 1, 2021. doi:10.1001/jamaoncol.2021.1900

Over the past 30 years, a growing body of evidence has emerged demonstrating that many patients with systemic cancer experience cancer-related cognitive impairments (CRCIs).1 Difficulties with memory, language, learning, attention, and processing speed (outside of that which would be expected because of normal aging) are increasingly observed among long-term survivors of cancer. Traditionally, CRCI symptoms were thought to be caused only by the neurotoxic effects of cancer therapies; therefore, they were appropriately termed chemoradiation-related cognitive impairments (also known as “chemobrain” or “brainfog”).

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