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Comment & Response
July 8, 2021

Reporting the Analytical Method Is Essential to Assessing Studies in Which Biomarkers Are a Major Study Objective—Reply

Author Affiliations
  • 1Breast Unit, Kliniken Essen-Mitte, Essen, Germany
  • 2Amedes MVZ Wagnerstibbe für Laboratoriumsmedizin, medizinische Mikrobiologie und Immunologie, Göttingen, Germany
  • 3German Breast Group, GBG Forschungs GmbH, Neu-Isenburg, Germany
JAMA Oncol. 2021;7(9):1403-1404. doi:10.1001/jamaoncol.2021.2046

In Reply We appreciate the comments from van Rossum et al in response to our recent randomized clinical trial on the efficacy of endocrine therapy for treatment of breast cancer in men.1 We investigated the extent of estradiol change in male patients with breast cancer receiving different kinds of endocrine therapies (tamoxifen, tamoxifen plus gonadotropin-releasing hormone analogue [GnRHa] or exemestane plus GnRHa) as the primary objective. Secondary objectives were changes in other sexual hormone parameters, libido, and quality of life, as well as adverse effects.

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