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August 5, 2021

Clinical Trial Enrollment of Racial, Ethnic, and Underrepresented Groups—Leveraging a Digital Infrastructure

Author Affiliations
  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville
JAMA Oncol. 2021;7(10):1447-1448. doi:10.1001/jamaoncol.2021.2680

In recent years, persistent disparities in cancer-related outcomes have heightened calls for inclusion of racial and ethnic minority individuals and other underrepresented populations in prospective clinical research. Researchers are keenly aware of the imperative to increase enrollment of diverse patient populations, but lack of trust, lack of awareness of clinical trial opportunities, limited access to care, and ineffective communication contribute to underenrollment. In addition to poor clinical trial accrual that has stagnated for more than a decade with fewer than 1 in 20 adult patients with cancer enrolled in ongoing studies and nearly 1 in 5 adult cancer clinical trials failing to reach completion, largely owing to poor accrual, it is evident that the current system of recruitment is not optimized to bring medical advances and prospective treatments to patients.1

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