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Comment & Response
August 5, 2021

Single-Dose Radiotherapy for Prostate Cancer—Lessons Learned From Single-Fraction High-Dose-Rate Brachytherapy

Author Affiliations
  • 1Department of Radiation Oncology, Beaumont Health, Royal Oak, Michigan
JAMA Oncol. 2021;7(10):1572. doi:10.1001/jamaoncol.2021.2691

To the Editor In their recent Original Investigation, Greco et al1 report early results from the PROSINT trial, which randomized 30 patients with intermediate-risk prostate cancer to 5-fraction stereotactic body radiotherapy (9 Gy × 5) vs 24-Gy single-dose radiotherapy (SDRT). After a median follow-up of 4 years, biochemical control rates were similar (86% vs 77%). As a proof-of-concept study, it forms the basis for larger, ongoing trials.

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