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Comment & Response
August 12, 2021

Errors in Reported Primary and Secondary Outcomes and Table Numbers in a Trial of Radiotherapy for Pain Relief in Patients With Bone Metastases

Author Affiliations
  • 1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
JAMA Oncol. 2021;7(10):1576-1577. doi:10.1001/jamaoncol.2021.3054

To the Editor On behalf of my coauthors, I write to address errors in our Original Investigation, “Single-Fraction Stereotactic vs Conventional Multifraction Radiotherapy for Pain Relief in Patients With Predominantly Nonspine Bone Metastases: A Randomized Phase 2 Trial,”1 that was published online on April 25, 2019, and in the June 2019 issue of JAMA Oncology. In this trial, 160 patients with radiologically confirmed painful bone metastases were randomly assigned to receive single-fraction stereotactic body radiotherapy (SBRT) or standard multifraction radiotherapy (MFRT). The primary end point was pain response, defined by international consensus criteria as a combination of pain score and analgesic use (daily morphine-equivalent dose) at 3 months. The trial found that SRBT was noninferior to MFRT.

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