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JAMA Oncology Clinical Challenge
September 2, 2021

Unilateral Leg Swelling in a Young Woman

Author Affiliations
  • 1McGaw Medical Center of Northwestern University, Chicago, Illinois
  • 2Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA Oncol. Published online September 2, 2021. doi:10.1001/jamaoncol.2021.3811

A 33-year-old woman with a history of hereditary bilateral retinoblastoma as an infant presented to a primary care clinic with 1 week of right lower extremity swelling. At age 8 months, she was treated with right enucleation and left eye radiotherapy (50.4 Gy). At age 4 years, she developed a recurrence of the retinoblastoma in the nasal cavity and was treated with 4 cycles of vincristine, doxorubicin, and cyclophosphamide followed by 1 cycle of cisplatin, etoposide, and intrathecal cytarabine.

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