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Comment & Response
September 9, 2021

What Is the Optimal Treatment for Vulnerable Older Women With Ovarian Cancer?

Author Affiliations
  • 1Department of Breast and Endocrine Surgery, National Center for Global Health and Medicine, Tokyo, Japan
  • 2Department of Breast and Medical Oncology, National Center for Global Health and Medicine, Tokyo, Japan
JAMA Oncol. 2021;7(11):1726-1727. doi:10.1001/jamaoncol.2021.4128

To the Editor In their randomized clinical trial, Falandry et al1 reported that in a population of vulnerable patients 70 years and older, single-agent carboplatin was associated with significantly worse outcomes than either conventional every-3-weeks or weekly carboplatin–paclitaxel. These results suggest that even vulnerable older women with newly diagnosed ovarian cancer should be offered a conventional carboplatin–paclitaxel combination regimen. Although all patients in the monotherapy group received carboplatin at an area under the curve of 5 mg/mL·min, similar to the every-3-weeks carboplatin–paclitaxel group, it is difficult to understand why the group receiving less-intense treatment had the worst feasibility. While this is an important clinical study that addresses an important clinical question, there are some concerns regarding the interpretation of this study.

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