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Comment & Response
September 9, 2021

What Is the Optimal Treatment for Vulnerable Older Women With Ovarian Cancer?

Author Affiliations
  • 1Faculty of Medicine, The University of Tokyo, Tokyo, Japan
  • 2Department of Medical Oncology, Kyorin University Faculty of Medicine, Tokyo, Japan
  • 3Department of Palliative Medicine, National Cancer Center Hospital, Tokyo, Japan
JAMA Oncol. 2021;7(11):1725-1726. doi:10.1001/jamaoncol.2021.4125

To the Editor We read with great interest the study by Falandry and colleagues in JAMA Oncology.1 When treating older patients with cancer, it is challenging when standard therapy cannot be implemented owing to low physical and organ reserve, even if performance status is good. The physician may reduce the dose and number of drugs when the patient is considered too vulnerable to receive standard therapy. This decision depends on the physician’s judgment. Therefore, a method is needed to distinguish between patients who have good tolerance to standard therapy and those who do not. In this study,1 the authors identified vulnerable patients based on the Geriatric Vulnerability Score (GVS) and examined whether single-agent carboplatin was better for this population than the standard doublet regimen. However, the completion rate and prognosis of the carboplatin arm did not exceed those of the control arm.

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