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Comment & Response
December 23, 2021

Metformin—A Thought-provoking Addition to Anticancer Therapies

Author Affiliations
  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
JAMA Oncol. 2022;8(2):303. doi:10.1001/jamaoncol.2021.6726

To the Editor We read with great interest the study by Tsakiridis and colleagues1 assessing the efficacy and safety of the addition of metformin to chemoradiotherapy in unresected locally advanced non–small cell lung cancer. Conclusions were drawn in this multicenter randomized clinical trial that the addition of metformin was associated with poorer outcomes and more adverse effects than chemoradiotherapy alone.

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