In Reply We thank Zhang et al and Goto for their interest in our recent article1 reporting the potential health benefits of an active lifestyle for cancer survivors. Cancer survival rates have substantially improved in past decades owing to early detection and advanced treatment, leading to a rapidly growing population of cancer survivors.2,3 Many cancer survivors live with increased risks of comorbidities and recurrence, poor quality of life, and shortened life expectancy.4 Therefore, it is urgent to ameliorate cancer survivorship through modifying lifestyle behavioral risks beyond clinical interventions. Our findings highlighted the association of a sedentary lifestyle with worsened survival after cancer.1