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January 2019, Vol 5, No. 1, Pages 3-126

Original Investigation

Risk of Hepatocellular Carcinoma in Patients Treated With Entecavir vs Tenofovir for Chronic Hepatitis B: A Korean Nationwide Cohort Study

Abstract Full Text
JAMA Oncol. 2019;5(1):30-36. doi:10.1001/jamaoncol.2018.4070

This cohort study uses data from the Korean National Health Insurance Service database to compare the risk of hepatocellular cancer associated with entecavir vs tenofovir disoproxil fumarate in patients receiving long-term treatment for chronic hepatitis B infection.

Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women

Abstract Full Text
has active quiz
JAMA Oncol. 2019;5(1):37-44. doi:10.1001/jamaoncol.2018.4280

This cohort study of women in the Nurses’ Health Study II assesses the association of obesity and weight gain since early adulthood with early-onset colorectal cancer.

Disease-Free and Overall Survival Among Patients With Operable HER2-Positive Breast Cancer Treated With Sequential vs Concurrent Chemotherapy: The ACOSOG Z1041 (Alliance) Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2019;5(1):45-50. doi:10.1001/jamaoncol.2018.3691

This phase 3 randomized clinical trial compares disease-free and overall survival among patients with operable HER2-positive breast cancer who received concurrent vs sequential administration of neoadjuvant chemotherapy.

Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing

Abstract Full Text
JAMA Oncol. 2019;5(1):51-57. doi:10.1001/jamaoncol.2018.2956

This study of patients with breast cancer, ovarian cancer, or both compared with controls uses whole-exome sequencing to investigate whether non-BRCA genes are associated with an increased risk of those cancers.

Total Medicare Costs Associated With Diagnosis and Treatment of Prostate Cancer in Elderly Men

Abstract Full Text
JAMA Oncol. 2019;5(1):60-66. doi:10.1001/jamaoncol.2018.3701

This large cohort study uses the SEER-Medicare database to evaluate the Medicare costs associated with diagnosis and treatment of nonmetastatic prostate cancer in men 70 years or older.

Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16–Related Cancer: A Phase 2 Clinical Trial

Abstract Full Text
JAMA Oncol. 2019;5(1):67-73. doi:10.1001/jamaoncol.2018.4051

This phase 2 clinical trial examines whether the efficacy of nivolumab is amplified through treatment with ISA 101, a synthetic long-peptide human papillomavirus 16 vaccine, in patients with incurable human papillomavirus 16–positive cancer.

Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer: A Phase 1 Study

Abstract Full Text
JAMA Oncol. 2019;5(1):74-82. doi:10.1001/jamaoncol.2018.4224

This phase 1 study evaluates the safety, clinical activity, and biomarkers associated with the use of single-agent atezolizumab in women with metastatic triple-negative breast cancer.

Continuation of Bevacizumab vs Cetuximab Plus Chemotherapy After First Progression in KRAS Wild-Type Metastatic Colorectal Cancer: The UNICANCER PRODIGE18 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2019;5(1):83-90. doi:10.1001/jamaoncol.2018.4465

This open-label, randomized phase 2 trial evaluates progression-free survival with chemotherapy plus bevacizumab vs cetuximab among patients with progression of metastatic colorectal cancer (mCRC) after bevacizumab plus chemotherapy.

Accuracy and Methodologic Challenges of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis: A Systematic Review and Meta-analysis

Abstract Full Text
online only
JAMA Oncol. 2019;5(1):e182815. doi:10.1001/jamaoncol.2018.2815

This systematic review and meta-analysis examines the diagnostic accuracy of volatile organic compound (VOC)–based exhaled breath tests for cancer and the challenges and strategies inherent in the use of breath testing for cancer diagnosis.

Alisertib in Combination With Weekly Paclitaxel in Patients With Advanced Breast Cancer or Recurrent Ovarian Cancer: A Randomized Clinical Trial

Abstract Full Text
online only
JAMA Oncol. 2019;5(1):e183773. doi:10.1001/jamaoncol.2018.3773

This phase 1 and 2 clinical trial examines progression-free survival in patients with ovarian or breast cancer treated with alisertib in combination with paclitaxel vs paclitaxel alone.

Brief Report

Association of Gleason Grade With Androgen Deprivation Therapy Duration and Survival Outcomes: A Systematic Review and Patient-Level Meta-analysis

Abstract Full Text
JAMA Oncol. 2019;5(1):91-96. doi:10.1001/jamaoncol.2018.3732

This meta-analysis examines the association of Gleason grade with the effectiveness of androgen deprivation therapy with radiotherapy in treating patients with high-risk prostate cancer.

Research Letter

Association Between Polycystic Ovary Syndrome and Cancer Risk

Abstract Full Text
JAMA Oncol. 2019;5(1):106-107. doi:10.1001/jamaoncol.2018.5188

This cohort study of Swedish register data examines the association between polycystic ovary syndrome and cancer risk in females aged 15 to 50 years between 1985 and 2009.

Assessment of Frequency and Reporting of Changes in Cancer Trial Design After Initiation of Patient Accrual

Abstract Full Text
JAMA Oncol. 2019;5(1):107-109. doi:10.1001/jamaoncol.2018.5877

This study matches entries in ClinicalTrials.gov for cancer drug trials at initiation of the trial with later entries and with journal reports of the trials to assess modifications in trial design, external factors associated with such modifications, and transparency in reporting them.

Review

Optimizing Cancer Treatment Using Game Theory: A Review

Abstract Full Text
JAMA Oncol. 2019;5(1):96-103. doi:10.1001/jamaoncol.2018.3395

This review approaches cancer treatment as a game theoretic contest between the physician’s therapy and the cancer cells’ resistance strategies and suggests how treatment strategies can be improved by exploiting the critical asymmetries between the opposing sides in this contest.

JAMA Oncology Clinical Challenge

A Lesion on the Scalp

Abstract Full Text
has active quiz
JAMA Oncol. 2019;5(1):104. doi:10.1001/jamaoncol.2018.3685

A 67-year-old man presented with a rapidly enlarging, itchy scalp lesion without generalized pruritus first noticed 3 months earlier as a pimple. What is your diagnosis?

Viewpoint

Decentered Crowdfunded Clinical Studies—Open a New Era of Medical Research

Abstract Full Text
JAMA Oncol. 2019;5(1):9-10. doi:10.1001/jamaoncol.2018.4650

This Viewpoint describes a process of conducting medical research that uses online crowdfunding as a model for recruiting and reviewing investigators and data.

Redefining the Role of Prophylactic Cranial Irradiation in the Modern Era of Active Surveillance in Small Cell Lung Cancer

Abstract Full Text
JAMA Oncol. 2019;5(1):11-12. doi:10.1001/jamaoncol.2018.4833

This Viewpoint discusses the role of prophylactic cranial irradiation in small cell lung cancer in the current setting of active surveillance via magnetic resonance imaging.

Hypofractionated Nodal Irradiation for Breast Cancer: A Case for Caution

Abstract Full Text
JAMA Oncol. 2019;5(1):13-14. doi:10.1001/jamaoncol.2018.5061

This Viewpoint discusses the use of hypofractionation for regional nodal irradiation as part of radiotherapy for breast cancer and the importance of waiting for results of long-term prospective studies.

Editorial

Tenofovir vs Entecavir for Hepatocellular Carcinoma Prevention in Patients With Chronic Hepatitis B: One of These Things Is Not Like the Other

Abstract Full Text
JAMA Oncol. 2019;5(1):17-18. doi:10.1001/jamaoncol.2018.4039
Invited Commentary

Hereditary Breast and Ovarian Cancer Testing in the Genomic Era

Abstract Full Text
JAMA Oncol. 2019;5(1):58-59. doi:10.1001/jamaoncol.2018.3034
JAMA Oncology Patient Page

Palliative Care

Abstract Full Text
free access
JAMA Oncol. 2019;5(1):126. doi:10.1001/jamaoncol.2018.4962

This Patient Page defines palliative care and explains who may most benefit, when it is most appropriate, and which clinicians might help administer it.

Cancer Care Chronicles

Social Media and Gender Equity in Oncology

Abstract Full Text
JAMA Oncol. 2019;5(1):15-16. doi:10.1001/jamaoncol.2018.4647

This article illustrates how social media can create new communities within medicine and, in particular, advance gender equity in oncology.

Comment & Response

Detecting a Survival Benefit to Dose Escalation

Abstract Full Text
JAMA Oncol. 2019;5(1):109-110. doi:10.1001/jamaoncol.2018.5055

Detecting a Survival Benefit to Dose Escalation—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):110. doi:10.1001/jamaoncol.2018.5093

Competing Risks for a Diagnosis of Invasive Breast Cancer

Abstract Full Text
JAMA Oncol. 2019;5(1):110-111. doi:10.1001/jamaoncol.2018.5058

Competing Risks for a Diagnosis of Invasive Breast Cancer—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):111. doi:10.1001/jamaoncol.2018.5102

Circulating Tumor Cells and Radiotherapy Benefit in Early Breast Cancer

Abstract Full Text
JAMA Oncol. 2019;5(1):111-112. doi:10.1001/jamaoncol.2018.5077

Circulating Tumor Cells and Radiotherapy Benefit in Early Breast Cancer—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):112. doi:10.1001/jamaoncol.2018.5108

Regional Hyperthermia With Neoadjuvant Chemotherapy for Treatment of Soft Tissue Sarcoma

Abstract Full Text
JAMA Oncol. 2019;5(1):112-113. doi:10.1001/jamaoncol.2018.5287

Regional Hyperthermia With Neoadjuvant Chemotherapy for Treatment of Soft Tissue Sarcoma

Abstract Full Text
JAMA Oncol. 2019;5(1):113-114. doi:10.1001/jamaoncol.2018.5296

Regional Hyperthermia With Neoadjuvant Chemotherapy for Treatment of Soft Tissue Sarcoma—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):114. doi:10.1001/jamaoncol.2018.5293

Body Composition and Overall Survival in Patients With Nonmetastatic Breast Cancer

Abstract Full Text
JAMA Oncol. 2019;5(1):114-115. doi:10.1001/jamaoncol.2018.5290

Body Composition and Overall Survival in Patients With Nonmetastatic Breast Cancer—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):115-116. doi:10.1001/jamaoncol.2018.5299

Burden of Multiple Myeloma in Taiwan

Abstract Full Text
JAMA Oncol. 2019;5(1):116. doi:10.1001/jamaoncol.2018.5523

Burden of Multiple Myeloma in Taiwan—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):116. doi:10.1001/jamaoncol.2018.5533

Anlotinib for Refractory Advanced Non–Small Cell Lung Cancer in China

Abstract Full Text
JAMA Oncol. 2019;5(1):116-117. doi:10.1001/jamaoncol.2018.5526

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Abstract Full Text
JAMA Oncol. 2019;5(1):117-118. doi:10.1001/jamaoncol.2018.5730

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor 2-Positive Breast Cancer—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):118. doi:10.1001/jamaoncol.2018.5739

Failure to Accurately Disclose Conflicts of Interest in Articles Published in JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2019;5(1):118-119. doi:10.1001/jamaoncol.2018.5674

Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6

Abstract Full Text
JAMA Oncol. 2019;5(1):119-120. doi:10.1001/jamaoncol.2018.6905

Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6

Abstract Full Text
JAMA Oncol. 2019;5(1):120. doi:10.1001/jamaoncol.2018.6908

Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6

Abstract Full Text
JAMA Oncol. 2019;5(1):120-121. doi:10.1001/jamaoncol.2018.6911

Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6—Reply

Abstract Full Text
JAMA Oncol. 2019;5(1):121-122. doi:10.1001/jamaoncol.2018.6914
Correction

Errors in Discussion Text and Table 1

Abstract Full Text
free access
JAMA Oncol. 2019;5(1):122. doi:10.1001/jamaoncol.2018.6918

Missing Conflict of Interest Disclosure

Abstract Full Text
free access
JAMA Oncol. 2019;5(1):122. doi:10.1001/jamaoncol.2018.5678
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2019;5(1):6. doi:10.1001/jamaoncol.2018.4126
In This Issue of JAMA Oncology

Highlights

Abstract Full Text
free access
JAMA Oncol. 2019;5(1):3. doi:10.1001/jamaoncol.2018.4125
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