This randomized clinical trial assesses whether treatment with stereotactic ablative radiotherapy vs observation improves oncologic outcomes in men with recurrent hormone-sensitive oligometastatic prostate cancer.
This randomized clinical trial compares durvalumab, with or without tremelimumab, with chemotherapy as a first-line treatment for metastatic non–small cell lung cancer.
This analysis of data from an ongoing open-label adaptively randomized phase 2 platform trial examines the efficacy of adding pembrolizumab to standard neoadjuvant chemotherapy in patients with early-stage, high-risk, ERBB2-negative breast cancer.
This cross-sectional analysis reports the retinoblastoma stage at diagnosis across the world during a single year, investigates associations between clinical variables and national income level, and investigates risk factors for advanced disease at diagnosis.
This nonrandomized clinical trial examines the safety and immunogenicity of the quadrivalent human papillomavirus vaccine in clinically stable women post–allogeneic transplant compared with female healthy volunteers.
This cohort study uses data from multiple US registries to analyze incidence, clinicopathologic characteristics, and outcomes for aggressive variants of papillary thyroid carcinoma.
This cohort study assesses whether circulating microRNA profiles could be used as biomarkers to improve the detection of lung cancer in symptomatic patients.
This next-generation exome sequencing study investigates the frequency of pathogenic or likely pathogenic germline genetic variants in known cancer-susceptibility genes among patients with osteosarcoma.
This secondary analysis examines the association of prostate-specific antigen levels before salvage radiotherapy and net benefit of long-term antiandrogen treatment added to salvage radiotherapy for men with recurrent prostate cancer after radical prostatectomy.
This phase 3 randomized clinical trial compares treatment with carboplatin plus pemetrexed followed by pemetrexed maintenance with docetaxel monotherapy for overall survival for elderly Japanese patients with advanced nonsquamous non–small cell lung cancer (NSCLC).
This secondary analysis of a randomized clinical trial assesses treatment outcomes in women with different biological types of breast cancer according to germline variant status of BRCA1/2 and non-BRCA1/2 breast cancer predisposition genes.
This narrative review discusses the key studies that have established the frequency and types of germline mutations in pancreatic ductal adenocarcinoma and implications for family members, strategies for genetic counseling, and treatment options for individuals with known germline mutations.
A middle-aged woman presented with a 7-month history of erythematous plaques on the lower legs and intermittent fever during the past 3 months. What is your diagnosis?
This Viewpoint describes infection prevention and control measures implemented in the care of patients with cancer during the COVID-19 outbreak in China.
This Viewpoint assesses the state of cancer survivorship care, discusses the association of chemotherapy with coronary artery disease, and calls readers to action.
This Viewpoint explores the use of molecular predictors of therapeutic responsiveness in assessing risk for patients with metastatic renal cell carcinoma.
This Viewpoint discusses the concept of precision cancer care delivery that includes patients, clinicians, data, and manufacturers.
This Patient Page describes the use of circulating tumor DNA testing to detect cancer-associated genetic variations and guide treatment recommendations.
In this essay, the author describes a magnifying glass, given to him by his mentor, that becomes for him the symbol of blocking out all distractions to view with focused intent the primary importance of the patient’s well-being in the practice of medicine.
Create a personal account or sign in to: