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Research Letter
February 2018

Restaging Abdominopelvic Computed Tomography Before Surgery After Preoperative Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

Author Affiliations
  • 1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, South Korea
  • 2Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, South Korea
  • 3Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, South Korea
  • 4Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, South Korea
  • 5Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, South Korea
JAMA Oncol. 2018;4(2):259-262. doi:10.1001/jamaoncol.2017.4596

Chemoradiotherapy (CRT) before surgery is a standard treatment for locally advanced cancer in the mid or low rectum. Long-course CRT delays surgery for several months, which may introduce a possibility, albeit small, for the tumor to make systemic progression or for occult metastasis to grow and manifest. Currently, there is no consensus regarding whether restaging abdominopelvic computed tomography (CT) is necessary before surgery after long-course CRT. Several studies have investigated this issue1-5; however, results were conflicting. Most of the studies were small.1,2,4,5 None of them compared the oncologic outcomes between patients who received and those who did not receive (as controls) the restaging CT.1-5 This study investigated restaging abdominopelvic CT performed before surgery after CRT in patients with locally advanced rectal cancer regarding its diagnostic yield and effect on postsurgical recurrence-free survival (RFS).

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