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June 2018

Data Presentation Error in Results Section

JAMA Oncol. 2018;4(6):891. doi:10.1001/jamaoncol.2018.1672

In the Original Investigation titled “Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer,”1 published online March 29, 2018, there were errors in the data presented in the second paragraph of the Comparison of TS With MSI and IHC subsection of the Results section. Five cases with negative test results were mistakenly reported as having false-positive results; the second and third sentences of the paragraph should thus read as follows: “Three hundred sixty-three cases had a negative screening test result and 76 cases had a positive screening test result based on TS. Of the 76 cases with a positive screening test result, 58 had LS and 18 were considered false-positive results (including 9 cases with double somatic MMR mutations and 9 with MLH1 methylation).” These errors do not affect the overall results or any of the sensitivity, specificity, positive predictive value, or negative predictive value numbers. This article has been corrected online.

Hampel  H, Pearlman  R, Beightol  M,  et al.  Assessment of tumor sequencing as a replacement for Lynch syndrome screening and current molecular tests for patients with colorectal cancer  [published online March 29, 2018].  JAMA Oncol. doi:10.1001/jamaoncol.2018.0104Google Scholar