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In This Issue of JAMA Oncology
May 2019


JAMA Oncol. 2019;5(5):592. doi:10.1001/jamaoncol.2018.4755


Oudard and colleagues performed a randomized phase 3 trial to determine whether androgen-deprivation therapy (ADT) plus docetaxel is superior to ADT alone for the treatment of high-risk nonmetastatic prostate cancer. Results showed that ADT plus docetaxel did not significantly improve prostate-specific antigen (PSA) progression-free survival in patients with high-risk prostate cancer and increasing PSA levels after primary local therapy. Vogelzang provides an Invited Commentary.

Invited Commentary

In a 3-arm randomized clinical trial, Cheville and colleagues investigated whether telerehabilitation could limit functional impairment in patients with late-stage cancer. Over a 6-month intervention period, the telerehabilitation-alone arm had improved function and quality of life compared with the control arm and the telerehabilitation plus pharmacological pain management arm. Both telerehabilitation alone and telerehabilitation plus pharmacological pain management were associated with a greater likelihood of being discharged home. However, telerehabilitation alone could improve functional outcomes and pain without the addition of pharmacological pain management. Patel provides an Invited Commentary.

Invited Commentary

In this record linkage study, Kok and colleagues investigated the incidence of and risk factors for benign solid tumors, especially those that can be considered precursors to cancer, in patients treated for childhood cancer. The study included 5843 survivors of childhood cancer and 883 siblings without cancer from the Dutch Childhood Oncology Group–Long-Term Effects After Childhood Cancer cohort. The median follow-up was 22.7 years. Results showed that childhood cancer survivors had about a 2-fold risk for developing subsequent benign tumors compared with siblings. These data and other findings provide information for surveillance guidelines for survivors of childhood cancers.

In this retrospective cohort study, Cagney and colleagues assessed the association and incidence of pachymeningeal seeding in patients with newly diagnosed symptomatic brain metastasis who received surgical resection and stereotactic radiation vs radiation alone. Results showed that resection was associated with pachymeningeal seeding but not with the development of leptomeningeal disease. Among patients with pachymeningeal seeding, neurologic death due to progressive brain disease was common. Without whole-brain radiotherapy, pachymeningeal seeding beyond the stereotactic radiation field is a potential complication of approaches that combine surgery and more directed radiotherapy techniques.