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Table 1.  Results of COVID-19 Testing at Memorial Sloan Kettering (MSK)
Results of COVID-19 Testing at Memorial Sloan Kettering (MSK)
Table 2.  Sex Distribution in Pediatric Cohort
Sex Distribution in Pediatric Cohort
1.
Zhu  N, Zhang  D, Wang  W,  et al; China Novel Coronavirus Investigating and Research Team.  A novel coronavirus from patients with pneumonia in China, 2019.   N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017PubMedGoogle ScholarCrossref
2.
Qiu  H, Wu  J, Hong  L, Luo  Y, Song  Q, Chen  D.  Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.   Lancet Infect Dis. 2020;S1473-3099(20)30198-5. doi:10.1016/S1473-3099(20)30198-5PubMedGoogle Scholar
3.
Lu  X, Zhang  L, Du  H,  et al; Chinese Pediatric Novel Coronavirus Study Team.  SARS-CoV-2 infection in children.   N Engl J Med. 2020;382(17):1663-1665. doi:10.1056/NEJMc2005073PubMedGoogle ScholarCrossref
4.
Choi  SH, Kim  HW, Kang  JM, Kim  DH, Cho  EY.  Epidemiology and clinical features of coronavirus disease 2019 in children.   Clin Exp Pediatr. 2020;63(4):125-132. doi:10.3345/cep.2020.00535PubMedGoogle ScholarCrossref
5.
Grasselli  G, Zangrillo  A, Zanella  A,  et al; COVID-19 Lombardy ICU Network.  Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy.   JAMA. 2020.PubMedGoogle Scholar
6.
Sutton  D, Fuchs  K, D’Alton  M, Goffman  D.  Universal screening for SARS-CoV-2 in women admitted for delivery.   N Engl J Med. 2020. doi:10.1056/NEJMc2009316PubMedGoogle Scholar
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    Research Letter
    May 13, 2020

    COVID-19 in Children With Cancer in New York City

    Author Affiliations
    • 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York
    • 2Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
    • 3Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
    JAMA Oncol. Published online May 13, 2020. doi:10.1001/jamaoncol.2020.2028

    Data on the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children,1-4 and in children with cancer specifically have been limited. Less than 1% of cases reported from China were in children younger than 10 years.3 The MSK Kids pediatric program at Memorial Sloan Kettering Cancer Center (MSK) is one of the largest pediatric cancer programs in the US. Starting in mid-March, 2020, we instituted a screening and testing plan to mitigate risk associated with coronavirus disease 2019 (COVID-19).

    Methods

    On presentation for outpatient or inpatient care, patients were screened for the presence of symptoms of COVID-19 or exposure to contacts with known SARS-CoV-2 infection. We also instituted testing for SARS-CoV-2 using a RT-PCR assay for 3 cohorts of individuals: (1) patients exposed to COVID-19 (screen positive) or with symptoms of infection (symptom positive); (2) asymptomatic patients (symptom negative) prior to deep sedation, myelosuppressive chemotherapy, or admission to the hospital; and (3) caregivers accompanying patients for admission or multiday outpatient chemotherapy. Data for this report were gathered a retrospective research protocol approved by the MSK institutional review board with waiver of informed consent owing to the retrospective and deidentified nature of the data used. Groups were compared using a 2-tailed Fisher exact test.

    Results

    Between March 10 and April 12, 2020, a total of 335 tests for SARS-CoV-2 were performed on pediatric patients and their caregivers (Table 1). Of the 178 unique pediatric patients (107 male and 71 female) tested (mean [SD] age 11.1 [8.5] years), 20 (11.2%) had positive test results (mean [SD] age 15.9 [6.6] years). Of patients specifically tested for positive screening or symptoms (screen positive or symptom positive), the rate of positivity for SARS-CoV-2 was 29.3%. By comparison, in the 120 asymptomatic patients without known exposure (screen negative and symptom negative) the rate of SARS-CoV-2 positivity was only 2.5% (29.3%; 95% CI, 18.1%-42.7% versus 2.5%; 95% CI, 0.5%-7.1%; P < .001) (Table 1). Of the 20 patients who tested positive for SARS-CoV-2, only 3 were female (Table 2), a significant sex skewing when compared with pediatric patients who tested negative (15%; 95% CI, 3%-38% vs 43%; 95% CI, 35%-51%; P = .02).

    Only 1 patient with COVID-19 illness required noncritical care hospitalization for COVID-19 symptoms. Three other patients without significant COVID-19 symptoms were admitted for concomitant fever and neutropenia, cancer morbidity, or planned chemotherapy. All other pediatric patients had mild symptoms and were managed at home.

    We also instituted testing of adult caregivers of patients (Table 1). Of the 74 individuals tested, 13 caregivers (17.6%) of 10 patients tested positive for SARS-CoV-2. Notably among 68 asymptomatic and unexposed caregivers (screen negative and symptom negative), 10 tested positive for SARS-CoV-2 (14.7%). Simultaneous detection of virus in patient and caregiver was found in 5 patient/caregiver dyads, whereas 5 patients were negative for virus despite close exposure to caregivers with COVID-19.

    Discussion

    Although this report is limited by small numbers, the data show that (1) the overall morbidity of COVID-19 in pediatric patients with cancer is low with only 5% requiring hospitalization for symptoms of COVID-19; (2) that the rate of SARS-CoV-2 infection among asymptomatic pediatric patients is very low; (3) that unrecognized SARS-CoV-2 infection in asymptomatic caregivers is a major infection control consideration; and (4) that consistent with the sex difference previously seen in adults with critical disease,5 there is a male bias in SARS-CoV-2 infections in children, suggesting a biological basis in skewed infectivity.

    This report suggests that pediatric patients with cancer may not be more vulnerable than other children2-4 to infection or morbidity resulting from SARS-CoV-2. Although the asymptomatic SARS-CoV carrier rate in children in the general population is not known, our testing of 120 asymptomatic pediatric patients with cancer revealed only a 2.5% rate of SARS-CoV-2 positivity. By comparison, we observed a 14.7% rate of SARS-CoV-2 positivity in their asymptomatic caregivers (2.5%; 95% CI, 0.5%-7.1% vs 14.7%; 95% CI, 7.3%-25.4%; P = .002), which closely matches the asymptomatic carrier rate in pregnant women in New York (13.5%).6 Together, our results do not support the conjecture that children are a reservoir of unrecognized SARS-CoV-2 infection.

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    Article Information

    Corresponding Author: Andrew L. Kung, MD, PhD, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 (kunga@mskcc.org).

    Accepted for Publication: April 27, 2020.

    Published Online: May 13, 2020. doi:10.1001/jamaoncol.2020.2028

    Author Contributions: Drs Boulad and Kung had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

    Concept and design: Boulad, Kung.

    Acquisition, analysis, or interpretation of data: All authors.

    Drafting of the manuscript: Boulad, Kung.

    Critical revision of the manuscript for important intellectual content: All authors.

    Statistical analysis: Mauguen, Kung.

    Administrative, technical, or material support: Bouvier, Kung.

    Supervision: Kamboj, Kung.

    Funding/Support: These studies were supported by internal institutional funding from the Memorial Sloan Kettering Cancer Center.

    Role of the Funder/Sponsor: The Memorial Sloan Kettering Cancer Center had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

    Additional Contributions: We thank the healthcare providers who conducted the SARS-CoV-2 testing and responded to COVID-19 illness described in this report.

    References
    1.
    Zhu  N, Zhang  D, Wang  W,  et al; China Novel Coronavirus Investigating and Research Team.  A novel coronavirus from patients with pneumonia in China, 2019.   N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017PubMedGoogle ScholarCrossref
    2.
    Qiu  H, Wu  J, Hong  L, Luo  Y, Song  Q, Chen  D.  Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.   Lancet Infect Dis. 2020;S1473-3099(20)30198-5. doi:10.1016/S1473-3099(20)30198-5PubMedGoogle Scholar
    3.
    Lu  X, Zhang  L, Du  H,  et al; Chinese Pediatric Novel Coronavirus Study Team.  SARS-CoV-2 infection in children.   N Engl J Med. 2020;382(17):1663-1665. doi:10.1056/NEJMc2005073PubMedGoogle ScholarCrossref
    4.
    Choi  SH, Kim  HW, Kang  JM, Kim  DH, Cho  EY.  Epidemiology and clinical features of coronavirus disease 2019 in children.   Clin Exp Pediatr. 2020;63(4):125-132. doi:10.3345/cep.2020.00535PubMedGoogle ScholarCrossref
    5.
    Grasselli  G, Zangrillo  A, Zanella  A,  et al; COVID-19 Lombardy ICU Network.  Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy.   JAMA. 2020.PubMedGoogle Scholar
    6.
    Sutton  D, Fuchs  K, D’Alton  M, Goffman  D.  Universal screening for SARS-CoV-2 in women admitted for delivery.   N Engl J Med. 2020. doi:10.1056/NEJMc2009316PubMedGoogle Scholar
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