Presymptomatic Awareness of Germline Pathogenic BRCA Variants and Associated Outcomes in Women With Breast Cancer | Breast Cancer | JAMA Oncology | JAMA Network
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Gabai-Kapara  E, Lahad  A, Kaufman  B,  et al.  Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2.   Proc Natl Acad Sci U S A. 2014;111(39):14205-14210. doi:10.1073/pnas.1415979111PubMedGoogle ScholarCrossref
Marchetti  C, De Felice  F, Palaia  I,  et al.  Risk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers.   BMC Womens Health. 2014;14(1):150. doi:10.1186/s12905-014-0150-5PubMedGoogle ScholarCrossref
Heemskerk-Gerritsen  BAM, Jager  A, Koppert  LB,  et al.  Survival after bilateral risk-reducing mastectomy in healthy BRCA1 and BRCA2 mutation carriers.   Breast Cancer Res Treat. 2019;177(3):723-733. doi:10.1007/s10549-019-05345-2PubMedGoogle ScholarCrossref
Metcalfe  K, Eisen  A, Senter  L,  et al; Hereditary Breast Cancer Clinical Study Group.  International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation.   Br J Cancer. 2019;121(1):15-21. doi:10.1038/s41416-019-0446-1PubMedGoogle ScholarCrossref
Daly  MB, Pilarski  R, Yurgelun  MB,  et al; National Comprehensive Cancer Network.  NCCN guidelines insights: genetic/familial high-risk assessment: breast, ovarian, and pancreatic, version 1.2020.   J Natl Compr Canc Netw. 2020;18(4):380-391. doi:10.6004/jnccn.2020.0017PubMedGoogle ScholarCrossref
Domchek  S, Robson  M.  Broadening criteria for BRCA1/2 evaluation: placing the USPSTF recommendation in context.   JAMA. 2019;322(7):619-621. doi:10.1001/jama.2019.9688PubMedGoogle ScholarCrossref
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    Research Letter
    July 9, 2020

    Presymptomatic Awareness of Germline Pathogenic BRCA Variants and Associated Outcomes in Women With Breast Cancer

    Author Affiliations
    • 1Breast Surgery Unit, Department of Surgery, Shaare Zedek Medical Center, Jerusalem, Israel
    • 2Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel
    • 3Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel
    • 4Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    • 5Breast Imaging Unit, Department of Imaging, Shaare Zedek Medical Center, Jerusalem, Israel
    • 6Departments of Radiation Oncology and Medicine, University of Colorado, Anschutz Medical Campus, Aurora
    JAMA Oncol. 2020;6(9):1460-1463. doi:10.1001/jamaoncol.2020.2059