Immune Responses to SARS-CoV-2 Among Patients With Cancer: What Can Seropositivity Tell Us? | Oncology | JAMA Oncology | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Views 5,114
Citations 0
May 28, 2021

Immune Responses to SARS-CoV-2 Among Patients With Cancer: What Can Seropositivity Tell Us?

Author Affiliations
  • 1Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 2Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, Tennessee
  • 3Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee
  • 4Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania
JAMA Oncol. Published online May 28, 2021. doi:10.1001/jamaoncol.2021.2096

Patients with cancer are at risk for immune dysregulation related to underlying malignant disease as well as receipt of immunomodulatory cancer therapy. A notable concern is that patients with cancer may not mount a robust protective immune response to SARS-CoV-2 infection or vaccination.1 This risk seems most pronounced in patients with hematologic cancers: in a study of 167 patients with chronic lymphocytic leukemia in Israel who had received both doses of the BNT162b2 messenger RNA (mRNA) vaccine (Pfizer-BioNTech) for COVID-19, only 39.5% had a positive antibody response, and this proportion was even lower (16%) among patients on active treatment.2 Patients with solid malignant neoplasms may have a more preserved immune response—of 261 patients with cancer in New York City who had tested positive for SARS-CoV-2, the rate of seroconversion was 94.5% for those with solid tumors compared with 81.7% with hematologic cancers.3

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words