This randomized clinical trial examines the effect of programmed cell death 1 immune checkpoint inhibition with nivolumab on overall survival for patients with recurrent glioblastoma.
This cohort study assesses overall survival by comparing 4 reduced-intensity conditioning and nonmyeloablative conditioning regimens in allogeneic hematopoietic cell transplantation treatment for patients with non-Hodgkin lymphoma.
This systematic review and meta-analysis quantifies the risk of recurrence and death associated with minimally invasive vs open radical hysterectomy for early-stage cervical cancer in observational studies optimized to control for confounding.
This cohort study compares the overall survival, disease progression, and other outcomes of stereotactic radiosurgery with those of whole-brain radiotherapy in patients with brain metastases from small cell lung cancer.
This multicenter cohort study assesses the accuracy of each definition of hyperprogressive disease to identify the frequency and associations with poorer outcomes of immune-checkpoint inhibitor therapy in patients with advanced non–small cell lung cancer and offers an optimized and homogenized definition based on all previous criteria for identifying hyperprogressive disease.
This interventional clinical trial examines the safety and tolerability of osimertinib and bevacizumab combination treatment and assesses the 12-month progression-free survival of the combination in patients with metastatic EGFR-mutant lung cancers.
This cohort study evaluates the association of participation in mental health treatment, housing support, or employment support programs with stage at diagnosis, receipt of stage-appropriate treatment, and mortality among US veterans with a preexisting mental health disorder and a diagnosis of non–small cell lung cancer.
This secondary analysis of the TARGIT-A randomized clinical trial compares the effect of delayed second-procedure targeted intraoperative radiotherapy (TARGIT-IORT) with whole-breast external beam radiotherapy (ERBT) on local recurrence at 5 years and long-term survival outcomes among women with early breast cancer.
This single-arm, multicenter phase 2 trial investigates the efficacy and safety of low-dose erlotinib in elderly or frail patients with EGFR mutation–positive non–small cell lung cancer.
This nonrandomized phase 2 study assesses the feasibility and safety of durvalumab treatment in adults with advanced solid tumors and HIV-1 infection.
This systematic review and meta-analysis evaluates the association of immune checkpoint inhibitor treatment with overall response rate, disease control rate, overall survival, and progression-free survival in patients with microsatellite instability-high cancers.
This study analyzes the incidence of opioid-associated deaths in cancer survivors vs the general population in the US from 2006 through 2016 using National Center for Health Statistics death certificate data.
This cohort study examines the association between prescription drug monitoring program mandates with and without a cancer exemption and the percent of oncologists’ patients with any opioid prescription covered by Medicare Part D.
This interrupted time series analysis evaluates the association of nudges with zoledronate prescription vs more expensive denosumab.
This case series study uses Medicare 2011-2019 Hospice Cost Report Data to analyze trends in the proportion of freestanding hospices in the United States providing radiotherapy and chemotherapy, as well as the expenses incurred for providing these therapies.
This cross-sectional study reviews the medical records of 1524 patients with cancer treated at a single tertiary care hospital in Wuhan, China, to evaluate the characteristics associated with transmission of the SARS-CoV-2 virus.
This cohort study examines the association between the use of minimally invasive surgery, capsule rupture, and survival among women with stage I epithelial ovarian cancer.
This systematic review evaluates the literature and reports the incidence, time of diagnosis, and nature of therapy-related myeloid neoplasms after peptide receptor radionuclide therapy.
A 75-year old woman with a history of follicular lymphoma and breast cancer presents with gradual vision loss and confusion; magnetic resonance imaging reveals hyperintensity in the left occipital and temporal lobes. What is your diagnosis?
This Viewpoint describes the importance of sharing data from completed trials to strengthen and guide further research.
This Viewpoint advocates for the consideration of hippocampal-sparing radiotherapy in patients with gliomas to mitigate treatment-related adverse events.
This Viewpoint highlights the importance of understanding the sources and variations in people’s notions of cancer risk.
In this essay, the author describes her experience being pregnant during the coronavirus disease 2019 pandemic.
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