In a study to derive reliable estimates of cancer risk for CDH1 mutation carriers, Hansford et al conclude that targeted panel sequencing is an efficient way to triage candidate families for broader whole-genome sequencing analysis.
In a study to assess patient demands or requests for medical tests or treatments, Gogineni et al found that in fewer than 9% of encounters do patients demand or request tests or treatments, and most of those are clinically appropriate.
This genomic profiling study found that almost all carcinomas of unknown primary site harbored at least 1 clinically relevant genomic alteration with potential to influence and personalize therapy.
This survey study finds that physician-controlled (vs shared) decision making on cancer treatment is associated with lower ratings of care quality and physician communication.
This study sought to determine population-based predictors for treatment and use of watchful waiting or active surveillance for patients with indolent prostate cancer. The authors found increased use of radiotherapy among these patients, with limited to no correlation with limited to no correlation with tumor biology.. Further research into the contributing factors that drive decision-making recommendations is needed.
The prevalence of cancer and precancer of the uterus in women who undergo myomectomy with or without electric power morcellation is low, but risk increases with age, so electric power morcellation should be used with caution in older women undergoing myomectomy.
Maddocks et al review 4 sequential trials of ibrutinib in patients with chronic lymphocytic leukemia, confirming ibrutinib to be an effective therapy, with outcomes data showing poor prognosis after therapy discontinuation.
Substantial progress has been made in cancer diagnosis and treatment, resulting in a steady improvement in cancer survival. The degree of improvement by age, race, and sex remains unclear. The authors sought to quantify the degree of survival improvement over time by age, race, and sex in the United States. Significant improvements in survival were found for cancers of the colon or rectum, breast, prostate, lung, and liver. Improvements were more pronounced for younger patients.
This review found that stem cell transplant is the current treatment of choice for high-risk myelofibrosis; for all other patients requiring treatment, the authors suggest participation in clinical trials because currently available drugs are palliative and not shown to be disease modifying.
A man in his 60s presented for further evaluation of a right inguinal and scrotal rash that had started 4 years prior as a dime-sized, pink, scaly area in the right inguinal crease and was pruritic. What is your diagnosis?
This Viewpoint advocates avoiding use of the phrase “losing the battle with cancer” when a patient dies of advanced disease because the warlike analogies are inappropriate for patients with cancer.