This prospective study of men with castration-resistant prostate cancer found that taxanes are more efficacious than enzalutamide or abiraterone therapy in men with androgen receptor splice variant 7 detected in circulating tumor cells; this may thus serve as a treatment selection biomarker.
This cross-sectional study of registry data and records from a large, integrated health care delivery system (years 2001-2010) found that 68% of patients who died between ages 15 and 40 years received at least 1 form of medically intensive end-of-life care.
This nationally representative proxy survey of 1985 cancer decedents older than 50 years found that, while advance care planning has improved in some domains, the improvement did not increase communication of end-of-life care decisions.
The Women’s Health Initiative Clinical Trial determined that there is an associations of overweight and obesity with risk of postmenopausal invasive breast cancer in postmenopausal after extended follow-up.
This retrospective study of patients with cardiovascular implantable electronic devices who subsequently received radiotherapy found that all cases of single-event upset malfunction occurred in the setting of notable neutron production.
This cohort study analyzes the association between Parkinson disease (PD) and risk of cancer using data obtained from the Taiwan National Health Insurance Research Database and concludes that PD is associated with most cancers in Taiwan and that ethnicity and environmental exposures may be important in disease pathogenesis.
This randomized clinical trial evaluated fedratinib therapy in patients with primary or secondary (post–polycythemia vera or post–essential thrombocythemia) myelofibrosis and found it to be effective but accompanied by toxic effects, which led to discontinuation of clinical development.
This study found that the amount of tissue Fusobacterium nucleatum is inversely associated with CD3+ T-cell density in colorectal carcinoma tissue.
This observational report describes a new genotyping method to establish the diagnosis of low-cellularity tumors like glioma that might be adapted to point-of-care diagnosis of other lesions similarly defined by highly recurrent somatic mutations.
This medical record review of patients who developed panniculitis during ibrutinib treatment for lymphoid leukemias describes 5 patients who developed this condition.
This literature review of axillary lymph node metastasis of primary colorectal cancer summarizes 6 case reports of patients with this condition.
This systematic review found that, for patients with multiple brain metastases from melanoma, emerging data exist to support the notion that stereotactic radiosurgery in combination with targeted therapies or immune therapy may obviate the need for whole-brain radiotherapy.
Deeg and Steuten address the financial, societal, and individual costs of aggressive treatment with curative intent in older patients with hematologic cancers and suggest that in some cases, palliative care might be a preferred alternative.
This Viewpoint discusses the incorporation of large databases using artificial intelligence into large cancer open networks to inform, educate, and help cancer treatment and research.
This Invited Commentary examines some of the complexities of end-of-life cancer care that may overwhelm advance directive implementation.
Adjuvant therapy is explained as cancer treatment given after the main treatment to increase the main treatment’s chances of success.
The author argues that the randomness of mutations that cause cancer must not be allowed to destroy the meaningfulness of the affected patient’s life.
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