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August 2019 - April 2015

Decade

Year

Issue

August 2015, Vol 1, No. 5, Pages 557-698

Original Investigation

Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer

Abstract Full Text
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JAMA Oncol. 2015;1(5):582-591. doi:10.1001/jamaoncol.2015.1341

This prospective study of men with castration-resistant prostate cancer found that taxanes are more efficacious than enzalutamide or abiraterone therapy in men with androgen receptor splice variant 7 detected in circulating tumor cells; this may thus serve as a treatment selection biomarker.

End-of-Life Care Intensity Among Adolescent and Young Adult Patients With Cancer in Kaiser Permanente Southern California

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JAMA Oncol. 2015;1(5):592-600. doi:10.1001/jamaoncol.2015.1953

This cross-sectional study of registry data and records from a large, integrated health care delivery system (years 2001-2010) found that 68% of patients who died between ages 15 and 40 years received at least 1 form of medically intensive end-of-life care.

Trends in Advance Care Planning in Patients With Cancer: Results From a National Longitudinal Survey

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JAMA Oncol. 2015;1(5):601-608. doi:10.1001/jamaoncol.2015.1976

This nationally representative proxy survey of 1985 cancer decedents older than 50 years found that, while advance care planning has improved in some domains, the improvement did not increase communication of end-of-life care decisions.

Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trials

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JAMA Oncol. 2015;1(5):611-621. doi:10.1001/jamaoncol.2015.1546

The Women’s Health Initiative Clinical Trial determined that there is an associations of overweight and obesity with risk of postmenopausal invasive breast cancer in postmenopausal after extended follow-up.

Radiotherapy-Induced Malfunction in Contemporary Cardiovascular Implantable Electronic Devices: Clinical Incidence and Predictors

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JAMA Oncol. 2015;1(5):624-632. doi:10.1001/jamaoncol.2015.1787

This retrospective study of patients with cardiovascular implantable electronic devices who subsequently received radiotherapy found that all cases of single-event upset malfunction occurred in the setting of notable neutron production.

Association Between Parkinson Disease and Risk of Cancer in Taiwan

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JAMA Oncol. 2015;1(5):633-640. doi:10.1001/jamaoncol.2015.1752

This cohort study analyzes the association between Parkinson disease (PD) and risk of cancer using data obtained from the Taiwan National Health Insurance Research Database and concludes that PD is associated with most cancers in Taiwan and that ethnicity and environmental exposures may be important in disease pathogenesis.

Safety and Efficacy of Fedratinib in Patients With Primary or Secondary Myelofibrosis: A Randomized Clinical Trial

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JAMA Oncol. 2015;1(5):643-651. doi:10.1001/jamaoncol.2015.1590

This randomized clinical trial evaluated fedratinib therapy in patients with primary or secondary (post–polycythemia vera or post–essential thrombocythemia) myelofibrosis and found it to be effective but accompanied by toxic effects, which led to discontinuation of clinical development.

Fusobacterium nucleatum and T Cells in Colorectal Carcinoma

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JAMA Oncol. 2015;1(5):653-661. doi:10.1001/jamaoncol.2015.1377

This study found that the amount of tissue Fusobacterium nucleatum is inversely associated with CD3+ T-cell density in colorectal carcinoma tissue.

Brief Report

Rapid Intraoperative Molecular Characterization of Glioma

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JAMA Oncol. 2015;1(5):662-667. doi:10.1001/jamaoncol.2015.0917

This observational report describes a new genotyping method to establish the diagnosis of low-cellularity tumors like glioma that might be adapted to point-of-care diagnosis of other lesions similarly defined by highly recurrent somatic mutations.

Research Letter

Panniculitis in Patients Undergoing Treatment With the Bruton Tyrosine Kinase Inhibitor Ibrutinib for Lymphoid Leukemias

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JAMA Oncol. 2015;1(5):684-686. doi:10.1001/jamaoncol.2015.0457

This medical record review of patients who developed panniculitis during ibrutinib treatment for lymphoid leukemias describes 5 patients who developed this condition.

Axillary Lymph Node Involvement, a Unique Pattern of Metastasis in BRAF-Mutant Colorectal Cancer

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JAMA Oncol. 2015;1(5):686-687. doi:10.1001/jamaoncol.2015.0569

This literature review of axillary lymph node metastasis of primary colorectal cancer summarizes 6 case reports of patients with this condition.

Review

Clinical Management of Multiple Melanoma Brain Metastases: A Systematic Review

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JAMA Oncol. 2015;1(5):668-676. doi:10.1001/jamaoncol.2015.1206

This systematic review found that, for patients with multiple brain metastases from melanoma, emerging data exist to support the notion that stereotactic radiosurgery in combination with targeted therapies or immune therapy may obviate the need for whole-brain radiotherapy.

JAMA Oncology Clinical Challenge

An Elderly Woman With Dyspnea

Abstract Full Text
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JAMA Oncol. 2015;1(5):679-680. doi:10.1001/jamaoncol.2015.1169
JAMA Oncology Diagnostic Test Interpretation

IGHV and Interphase Cytogenetics in a Patient With Chronic Lymphocytic Leukemia

Abstract Full Text
JAMA Oncol. 2015;1(5):681-682. doi:10.1001/jamaoncol.2015.1297
Viewpoint

Gene Mutation Profiling of Breast Cancers for Clinical Decision Making: Drivers and Passengers in the Cart Before the Horse

Abstract Full Text
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JAMA Oncol. 2015;1(5):569-570. doi:10.1001/jamaoncol.2015.0761

Therapy for Hematologic Cancers in Older Patients, Quality of Life, and Health Economics: Difficult Decisions

Abstract Full Text
JAMA Oncol. 2015;1(5):571-572. doi:10.1001/jamaoncol.2015.1084

Deeg and Steuten address the financial, societal, and individual costs of aggressive treatment with curative intent in older patients with hematologic cancers and suggest that in some cases, palliative care might be a preferred alternative.

Artificial Intelligence, Big Data, and Cancer

Abstract Full Text
JAMA Oncol. 2015;1(5):573-574. doi:10.1001/jamaoncol.2015.1203

This Viewpoint discusses the incorporation of large databases using artificial intelligence into large cancer open networks to inform, educate, and help cancer treatment and research.

From the JAMA Network

Cancer Care Delivery Research and the National Cancer Institute SEER Program: Challenges and Opportunities

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JAMA Oncol. 2015;1(5):677-678. doi:10.1001/jamaoncol.2015.0764
Editorial

Has the Time Arrived for Biomarker-Directed Therapy in Castration-Resistant Prostate Cancer?

Abstract Full Text
JAMA Oncol. 2015;1(5):577-579. doi:10.1001/jamaoncol.2015.1457

The Death Burden and End-of-Life Care Intensity Among Adolescent and Young Adult Patients With Cancer

Abstract Full Text
JAMA Oncol. 2015;1(5):579-580. doi:10.1001/jamaoncol.2015.2038
Invited Commentary

Advance Directives: Sometimes Necessary But Rarely Sufficient

Abstract Full Text
JAMA Oncol. 2015;1(5):609-610. doi:10.1001/jamaoncol.2015.2074

This Invited Commentary examines some of the complexities of end-of-life cancer care that may overwhelm advance directive implementation.

Obesity and Breast Cancer: Narrowing the Focus

Abstract Full Text
JAMA Oncol. 2015;1(5):622-623. doi:10.1001/jamaoncol.2015.1547

Parkinson Disease and Malignant Disease: Minding Cancer’s Own Business

Abstract Full Text
JAMA Oncol. 2015;1(5):641-642. doi:10.1001/jamaoncol.2015.1810

JAK/STAT Pathway Inhibitors and Neurologic Toxicity: Above All Else Do No Harm?

Abstract Full Text
JAMA Oncol. 2015;1(5):651-652. doi:10.1001/jamaoncol.2015.1591
Editor's Note

Participatory Gaps in the Advance Care Planning Process of Patients With Cancer

Abstract Full Text
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JAMA Oncol. 2015;1(5):610. doi:10.1001/jamaoncol.2015.2088

Safe Delivery of Radiotherapy to Patients With Pacemakers or Cardioverter-Defibrillator Devices

Abstract Full Text
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JAMA Oncol. 2015;1(5):632. doi:10.1001/jamaoncol.2015.1788
JAMA Oncology Patient Page

Adjuvant Therapy

Abstract Full Text
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JAMA Oncol. 2015;1(5):698. doi:10.1001/jamaoncol.2015.2095

Adjuvant therapy is explained as cancer treatment given after the main treatment to increase the main treatment’s chances of success.

Cancer Care Chronicles

The Implications of “Random Chance” in Cancer Genesis: Why Stochastic Can Be a Dirty Word

Abstract Full Text
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JAMA Oncol. 2015;1(5):575-576. doi:10.1001/jamaoncol.2015.0786

The author argues that the randomness of mutations that cause cancer must not be allowed to destroy the meaningfulness of the affected patient’s life.

Poetry and Oncology

The Oncologist’s Perspective: A Patient With Prostate Cancer

Abstract Full Text
JAMA Oncol. 2015;1(5):691. doi:10.1001/jamaoncol.2015.1844
Comment & Response

Truthfulness of More Optimistic vs Less Optimistic Messages for Patients With Advanced Cancer

Abstract Full Text
JAMA Oncol. 2015;1(5):687-688. doi:10.1001/jamaoncol.2015.1166

Truthfulness of More Optimistic vs Less Optimistic Messages for Patients With Advanced Cancer—Reply

Abstract Full Text
JAMA Oncol. 2015;1(5):688. doi:10.1001/jamaoncol.2015.1163

Watchful Waiting–Active Surveillance in Low-Risk Prostate Cancer

Abstract Full Text
JAMA Oncol. 2015;1(5):688-689. doi:10.1001/jamaoncol.2015.1214

Watchful Waiting–Active Surveillance in Low-Risk Prostate Cancer—Reply

Abstract Full Text
JAMA Oncol. 2015;1(5):689-690. doi:10.1001/jamaoncol.2015.1199
Correction

Errors in Author Names

Abstract Full Text
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JAMA Oncol. 2015;1(5):690. doi:10.1001/jamaoncol.2015.2892
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
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JAMA Oncol. 2015;1(5):563. doi:10.1001/jamaoncol.2014.248
In This Issue of JAMA Oncology

Highlights

Abstract Full Text
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JAMA Oncol. 2015;1(5):557. doi:10.1001/jamaoncol.2015.0726
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