This cohort study found that among women with primary invasive epithelial ovarian cancer, dose reduction for paclitaxel and carboplatin was associated with poorer survival, and body mass index was the strongest predictor of dose reduction.
In this pilot study of patients with newly diagnosed or smoldering multiple myeloma, carfilzomib-lenalidomide-dexamethasone therapy was tolerable and demonstrated high rates of minimal residual disease negativity.
This systematic review and meta-analysis determined that transcatheter arterial chemoembolization (TACE) plus radiotherapy was more therapeutically beneficial than TACE alone for treating hepatocellular carcinoma.
In a randomized clinical trial of previously inactive postmenopausal women, a 1-year prescription of moderate to vigorous exercise for 300 min/wk was superior to 150 min/wk for reducing total fat and several other adiposity measures, especially in obese women, but not intra-abdominal fat.
This multi-institutional, longitudinal cohort study finds that palliative chemotherapy did not improve quality of life near death for cancer patients with moderate or poor performance status and worsened quality of life near death for cancer patients with good performance status.
This systematic review finds that survival gains in first-line treatments of metastatic colorectal cancer over the last 22 years have been modest but steady.
This retrospective observational medical chart review determined that, overall, physicians tended to underestimate the risk of recurrence for many patients with gastrointestinal stromal tumors.
This study assesses the cost-effectiveness of low-dose computed tomographic scan screening for lung cancer within the Canadian health care system using the Cancer Risk Management Model.
This small case series shows that maternal plasma cell-free DNA sequencing for noninvasive prenatal testing also enables accurate presymptomatic detection of maternal tumors and treatment during pregnancy.
This case report describes the first use of vemurafenib in an infant with BRAF V600E–mutated Langerhans cell histiocytosis, showing improvement in the patient’s general health and eventual complete remission.
This Research Letter describes a patient, 10-weeks pregnant with dichorionic-diamniotic twins, diagnosed as having a stage IV exon 19 deletion adenocarcinoma. She was treated with erlotinib; both lung lesions became cystic, and all brain lesions were smaller.
This review categorizes acute myeloid leukemia into biologically defined groups and describes the evolving treatment approaches for each.
A man with transformed marginal zone lymphoma presented with intensely painful lesions on his left foot and pruritic rash on his left thigh that had started several days before the appearance of his plantar foot lesions. What is your diagnosis?
This Viewpoint discusses 3 principles of behavioral psychology that provide insight into how patients’ treatment preferences are influenced in serious illnesses.
This Viewpoint reviews the convergence of evidence in support of adjuvant chemotherapy for bladder cancer and proposes that despite the lack of level 1 evidence it is time for perioperative chemotherapy for bladder cancer (neoadjuvant or adjuvant) to become standard of care.
This Viewpoint discusses the differential prices of drugs in the United States vs Canada and England and cross-border drug importation. Competitive market forces would function better, lower cancer drug prices, and would benefit all parties.
This commentary argues that the greater effectiveness of targeted magnetic resonance/ultrasound fusion prostate biopsy will eventually result in its replacing the simple ultrasound procedure, but owing to its greater complexity and level of difficulty, the change will take some time.